Wisp Topical Spironolactone + Clindamycin Formula for Acne
Per month for 3 months
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Wisp Topical Spironolactone + Clindamycin Formula for Acne
Hormonal acne treatment with fewer side effects.
Looking for effective management of your hormonal acne without oral medications? Our clinically-proven, anti-androgen topical formula effectively treats hormonal acne in both men and women, with fewer systemic side effects.
- Topical Spironolactone 5%: Localized anti-androgen prescription active that targets excess oil production for clearer skin in 8 weeks
- Clindamycin 1.25%: Tackles redness and inflammation by reducing acne-causing bacteria
We also offer Oral Spironolactone to target hormonal imbalances from the inside out.
FSA & HSA accepted.
Wisp Topical Spironolactone + Clindamycin Formula for Acne
Topical vs. Oral Spironolactone
Our Topical Spironolactone formula works locally at the surface of the skin to reduce the excess oil caused by androgens, and fight inflammation and redness. Because the topical cream only acts where it is applied, it has fewer systemic side effects on the body. On the other hand, Oral Spironolactone acts throughout the body to reduce the effects of androgens—this is why the oral medication can also help with excess facial hair growth and hair loss caused by hormonal changes.
Depending on your needs, you may prefer one formula over the other, but both oral and topical Spironolactone are effective against hormonal acne. They can even be combined if you find you need extra acne-fighting power!
Benefits of Topical Spironolactone
- Includes Clindamycin to target acne-causing bacteria and prevent new breakouts
- Fewer systemic side effects compared to oral spironolactone
- Easily pair with Wisp’s Firm Up! Tretinoin Cream, Birth Control, or Oral Spironolactone to customize your routine, if clinically appropriate.
Medication Details
Topical Spironolactone FAQ
Wisp Care Team

One blocks the hormones, one battles the bacteria—Spironolactone and Clindamycin are the dynamic duo tackling both the cause and the chaos of acne.