A woman's hands holding a white pill bottle and a supplement capsule in front of a mauve background

Fact vs. Fiction:
Weight Loss Supplements

By Kathleen Morrison
October 31, 2024

The weight loss industry is filled with promises of quick fixes and miracle solutions, but how many of these claims hold up under scrutiny? With the rise of popular medications like Wegovy and Ozempic, the market for supplements that claim to provide rapid weight loss has exploded. Being able to separate fact from fiction is crucial when it comes to something as important as your health.

Let’s explore GLP-1 receptor agonists (such as Wegovy and Ozempic), debunk common myths about over-the-counter (OTC) supplements that claim to work similarly, and take a look at some of the natural ingredients with clinical evidence supporting their role in weight management. What works and what doesn’t in the world of weight loss supplements?

What are GLP-1 Medications?

GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medication originally developed to treat type 2 diabetes. These drugs, like Wegovy (semaglutide) and Ozempic, help regulate blood sugar and insulin levels by mimicking the action of a natural hormone (GLP-1) in the body. They also have a side effect that has made them popular for weight loss: they help reduce appetite and slow down digestion, making you feel full for longer periods.

Semaglutide, the active ingredient in both Wegovy and Ozempic, is one of the most commonly prescribed GLP-1 medications for weight management. Another option is compounded semaglutide, which are custom formulations combining semaglutide with other ingredients. These medications work by acting on the brain’s hunger centers and slowing the movement of food through the stomach, leading to decreased food intake and, ultimately, weight loss.

These drugs have shown significant promise in aiding weight loss, but they are prescription-only and must be used under medical supervision. However, the success and popularity of GLP-1 medications has sparked interest in over-the-counter alternatives that claim to replicate the effects of GLP-1 receptor agonists.

Are There Over-the-Counter GLP-1s?

Given the success of prescription GLP-1 medications, many companies have developed supplements that claim to boost GLP-1 levels or mimic the effects of these drugs. But is there any truth to these claims? To understand this, we need to delve into what GLP-1 actually does in the body.

GLP-1 is a hormone that plays a key role in regulating appetite, insulin secretion, and digestion. Prescription GLP-1 receptor agonists like Wegovy and Ozempic are synthetic versions of this hormone designed to directly interact with receptors in the brain and digestive system to curb hunger. Over-the-counter supplements, on the other hand, claim to either increase the body’s natural GLP-1 production or act in similar ways to facilitate weight loss.



A woman's hand holding a mobile phone showing information about Wisp's weight care treatment options in front of a pink background

Weight Care Consult

Prescription weight loss treatment and expert guidance to achieve your health goals safely and effectively.

Starting at $99.00/ month

Get Started
A plastic Wisp pill vial on a red surface with a pink background

Wisp Metabolic Support & GLP-1 Boost Capsules

This custom formulated, natural supplement includes clinically-studied ingredients to help you achieve your metabolic health goals.

Starting at $61.00

Get Started
Pill bottle on red board with pink background

Zofran (Ondansetron)

A prescription anti-nausea medication to treat nausea caused by new medication or antibiotics, hangovers, and indigestion.

Starting at $24.00

Get Started
Wisp Equalizing Probiotics on a red surface with a pink background

Wisp Equalizing Probiotics

Custom formulated by our doctors to support immune, gut, vaginal + oral health, cholesterol levels, and more.

Starting at $74.00

Get Started

Unfortunately, many of these claims are not backed by clinical evidence. Let’s break down a few common myths about these weight loss supplements:

  • Myth #1: Supplements can significantly boost your natural GLP-1 levels. Fact: There is currently no over-the-counter supplement that has been proven to directly increase GLP-1 production to the levels seen with prescription medications like Wegovy or Ozempic. While some ingredients may offer mild appetite-suppressing effects, they do not replicate the complex hormonal actions of GLP-1 receptor agonists.
  • Myth #2: OTC supplements can replace prescription GLP-1 medications. Fact: Supplements marketed as "natural GLP-1 boosters" are not substitutes for prescription medications. Prescription GLP-1 receptor agonists undergo rigorous testing for safety and efficacy, while most over-the-counter supplements lack the same level of scientific validation and regulation.
  • Myth #3: All-natural supplements are equally as effective as prescription drugs for weight loss.
    Fact: While some natural ingredients have been shown to support weight loss, they are generally less potent than prescription medications like GLP-1 receptor agonists. They may be effective when combined with a healthy diet and exercise, but they are not miracle cures.

Do Any Weight Loss Supplements Actually Work?

While many weight loss supplements make bold claims, there are a few natural ingredients that have been supported by clinical evidence. These ingredients may not work as rapidly or powerfully as prescription drugs, but they can play a role in weight management when used in conjunction with healthy lifestyle choices. Let’s explore some of the most promising ingredients:

  • Eriomin: A citrus extract that has shown promise in reducing oxidative stress and improving insulin sensitivity. This ingredient may help balance blood sugar levels, which can be beneficial for weight management by reducing cravings and supporting fat metabolism.
  • Dihydroberberine: A natural compound found in plants, berberine has been shown to have similar effects to certain diabetes medications by improving insulin sensitivity and regulating blood sugar levels. There’s also some evidence to suggest that berberine can also help improve metabolic function.
  • Black Ginger Extract: Black ginger extract has been studied for its potential to boost energy expenditure and decrease abdominal fat.
  • Lactobacillus paracasei: A probiotic strain that supports gut health, Lactobacillus paracasei has been linked to improved digestion and metabolism. A healthy gut microbiome can positively influence weight management by regulating the absorption of nutrients and reducing inflammation.
  • Magnesium: An essential mineral, magnesium plays a critical role in many bodily functions, including energy production and muscle function. Some studies suggest that adequate magnesium intake can help regulate insulin levels and support a healthy metabolism, making it an important nutrient for weight management.

While these ingredients won’t deliver the same dramatic results as prescription medications, they can offer support for those looking to manage their weight without a prescription.

Formulated by Doctors, Custom-Made

If you’re looking for a way to supplement your own fitness routine without prescriptions, our Metabolic GLP Support Capsules may be for you! Unlike many weight loss supplements on the market, this formula is crafted by doctors and includes a combination of the clinically-backed ingredients mentioned above: Eriomin®, dyhydroberberine, black ginger extract, Lactobacillus paracasei, and magnesium.

Designed to support metabolic health, improve digestion, and aid in weight management by leveraging the power of natural ingredients, our supplement complements your health routine with plant-based, clinically-studied ingredients. However, don’t use it in conjunction with other semaglutide or GLP-1 medications—this can result in dangerous side effects. Always consult with your healthcare provider before making life changes and if pregnant or nursing, taking medication, or have a medical condition.

When it comes to weight loss, there’s no shortage of products that promise quick results. Doing your research and arming yourself with knowledge is one way to take control of your health and fitness journey! Ask questions, look to trusted sources, and consult with a healthcare provider to get the best weight care options for you.

All product names, logos, brands, and other trademarks or images shown or mentioned are the property of the respective brand owners.

Keep reading