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Gonorrhea Treatment Guide

Application & Dosage

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Gonorrhea Treatment

This treatment plan reviews the risks and benefits of the treatment we are recommending. Please make sure to read it and the manufacturer's pamphlet that comes with the medicine. The manufacturer's pamphlet contains the full information on interactions, side effects, and other important information you should know about the medicine before you start.


You have stated that you wish to obtain treatment with oral Cefixime due to your exposure to Gonorrhea. Please note that the preferred primary treatment method with gonorrhea is an intramuscular injection of Ceftriaxone. If you have continued or worsening symptoms including fever or severe abdominal or back pain with treatment you will need to see an in-person provider for additional evaluation and alternative treatment.

This medication is Cefixime 400 mg which you are to take two tablets orally at once. This treatment will control the infection of the bacteria which can transmit during sexual activity with a colonized partner. Gonorrhea can oftentimes have no symptoms, but if symptoms do occur you can experience abnormal genital discharge, pain during urination, bleeding between your periods, painful or swollen testicles, rectal discharge, itching, soreness, bleeding, and painful bowel movements. Untreated gonorrhea infections can result in pelvic inflammatory disease in patients assigned female at birth which can cause complications with fertility in the future. Ensure to abstain from intercourse 7 days AFTER completing treatment AND when your symptoms are gone to prevent transmission to another partner and reinfection to yourself.

It is recommended to have STI testing performed 3 months after completing treatment to ensure you are no longer colonized with a bacterial STI.


This medicine, like all medications, may cause an allergic reaction if you are allergic to similar medicines or components. If you are allergic to any of the following please do not take the medicine and call or message us or see your doctor in person.

  • Caution with sensitivity to Penicillins—Amoxicillin, Penicillin, Augmentin, Dicloxacillin, Ampicillin, Nafcillin, Oxacillin
  • Cephalosporin antibiotics—Cephalexin, Cefotetan, Cefuroxime, Cefoxitin, Ceftriaxzone, Ceftazidime, Cefdinir
  • Beta-Lactam Antibiotics—Carbapenems, Monobactams, Beta-lactamase inhibitors


  • History of kidney problems or disease
  • History of liver problems or disease
  • History of cephalosporin-associated hemolytic anemia
  • Blood disorder

Pregnancy and Breastfeeding

Cefixime is considered safe and acceptable during pregnancy and is rated pregnancy class B. It crosses the placental barrier and is present in amniotic fluid.

No information is available on the use of Cefixime during breastfeeding, although cephalosporins are generally not to be expected to cause adverse effects in breastfed infants. Monitor the infant for gastrointestinal upset like diarrhea and thrush. Cefixime is acceptable in nursing mothers.

Medicine, Supplements, and Food

We have evaluated the specific health information you provided us, however if you are taking any of the medicines, foods, or supplements listed below call or message us before you take the medicine. Some of these can cause dangerous interactions with the medicine we are prescribing you and we will help you evaluate that risk and decide on an appropriate treatment plan. Please ensure your chart is up to date with your current medications, allergies, and medical conditions so your provider can safely treat you as this list may not be all inclusive.

  • Aminoglycoside antibiotics- Streptomycin, Neomycin, etc.
  • Probenecid
  • Vitamin K agonists—Warfarin
  • BCG, Cholera, and Typhoid vaccines

Emergency Side Effects

This medicine can cause dangerous and potentially life-threatening side effects. If any of the emergency side effects listed in the manufacturer’s pamphlet or those below happen to you please stop taking the medicine and call 911 or seek immediate medical help in person.

  • Sudden onset of chest pain or heart palpitations
  • Shortness of breath
  • Difficulty or painful swallowing
  • Severe skin rash and/or itching
  • Facial or throat swelling
  • Severe diarrhea or blood diarrhea
  • Significant fatigue, loss of appetite, or a yellow color of the skin or eyes

Other Side Effects

This medicine can also cause other side effects including (this list is not all inclusive):

  • Diarrhea
  • Abdominal discomfort- GERD, gas
  • Nausea and vomiting
  • Vaginal yeast infections
  • Dizziness
  • Headache
  • Fatigue


Accurate Information

We have evaluated your health history and your specific health information you provided and determined it is safe to proceed with oral Doxycycline Hycalate at this time. If your health history changes including diagnoses or medications please message or call us before you take the medicine to ensure it's safe to proceed. Some medications and conditions can cause dangerous interactions with the medicine we are prescribing and we will help you evaluate that risk and decide on an appropriate treatment plan.

Treatment Failure

This treatment is not guaranteed to be effective. It may not work or may only partially resolve the condition for which you are seeking treatment. If the treatment is not working, or if you are experiencing new or worsening symptoms, give us a call or message us anytime. If it is an emergency, call 911 or seek immediate medical help in person. You may need to seek alternative treatment such as those listed below or in the follow up plan.

Misdiagnosis or Delayed Diagnosis

Through telehealth, there is also a risk that we misdiagnose or fail to diagnose conditions that you may have which could affect our recommendation for treatment. This risk exists with a doctor in person as well but they may have additional resources to aid their evaluation. We use evidence-based practice and guidelines as well as clinical decision-making to minimize these risks.

Accepting or Declining Our Recommendation

We have based our recommendation on your specific case and medical guidelines, but there may be alternative treatments or strategies that may be helpful to you. Some may be more or less effective than what we provide. Some treatments may require an in-person exam or procedure which we can’t provide. Message us or talk to your doctor in person to discuss alternative treatments.

Share with Your In-Person Healthcare Team

You can access your records anytime. We strongly recommend that you update your in-person doctor, pharmacist, and the rest of your healthcare team to let them know about any new medicines you are taking or other changes in your health.

You can also ask us questions anytime and we are happy to help you share any information about your health with your in-person healthcare team.