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Metronidazole Oral BV Treatment

Application & Dosage

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Bacterial Vaginosis Management

This treatment plan reviews the risks and benefits of the treatment we are recommending. Please make sure to read it and the manufacturer's pamphlet that comes with the medicine. The manufacturer's pamphlet contains the full information on interactions, side effects, and other important information you should know about the medicine before you start.


You have stated that you wish to take a medication for your symptoms of bacterial vaginitis/vaginosis. Metronidazole, which you are to take 1 Tablet (500mg) 2 times each day (morning and evening) for 7 days, will decrease the overgrowth of this bacteria, which commonly lives in women’s reproductive organs. Signs of this infection include painless, foul-smelling discharge without itching or burning with urination. Bacterial vaginosis should not cause pain or discomfort during intercourse and cannot be transmitted between male/female sexual partners. It can be transferred between female/female sexual partners, but colonization does not mean overgrowth. It is the overgrowth of this bacteria, which is not harmful to your body, that causes the change in discharge with odor.


[Subscription patients only] You will automatically be sent a refill every 90 days (subject to a refill visit to help screen for side effects). You may request a refill early by logging into your Account (Subscriptions > Next Refill) or placing a new one-time order.

It is not wise to continue taking successive courses of oral antibiotics for any condition, particularly BV. Metronidazole has a black box warning issued by the FDA that it can be carcinogenic (cancer-causing), and is recommended against “unnecessary use”. Additionally, Recurrent oral antibiotics can result in bacterial mutation, even in other parts of your body, and can contribute to antibacterial resistance.

If your symptoms aren't getting better after you start taking the medicine or if you develop new or worsening symptoms such as fever, chills, nausea, vomiting, or pain, you should see a doctor in-person and call or message us immediately. Furthermore, if your symptoms are not simply vaginal odor and discharge, then an in-person pelvic exam with a physician is necessary to determine a correct diagnosis.

Active Ingredients

This medicine contains the following active ingredients. If you are allergic to any of these components, similar components, or any of the others components listed in the manufacturer's pamphlet do not take it and call or message us immediately:

  • Metronidazole


This medicine may cause an allergic reaction if you are allergic to similar medicines or components. If you are allergic to any of the following, please stop taking the medicine and message your wisp doctor, or seek an in-person:

  • Metronidazole (often prescribed to treat trichomoniasis)
  • Nitroimidazole derivatives, or any component of the formulation
  • Use of disulfiram within the past 2 weeks


We have evaluated your health history and the specific health information you provided us, however if anything changes and you develop or discover that one of these conditions applies to you please stop taking this medicine and call or message us immediately:

  • Pregnancy
  • Use of any alcohol or Antabuse
  • Central nervous system problems
  • Liver problems
  • Blood disorders

Pregnancy and Breastfeeding

Oral Metronidazole can potentially cause birth defects if taken in the first trimester of pregnancy. It is not recommended for use during breastfeeding due to the potential for side effects in the infant. In these cases, treatment may still be beneficial but topical treatment is the prefered route of application.

Emergency Side Effects

This medicine can cause dangerous and potentially life threatening side effects. If any of the emergency side effects listed in the manufacturer's pamphlet or those below happen to you please stop taking the medicine and call 911 or seek immediate medical help in-person:

  • Seizures
  • Anxiety or agitation
  • Difficulty swallowing or throat swelling
  • Jaundice or yellow skin
  • Liver and kidney disease
  • Severe skin rash or changes
  • Severe weakness or fatigue
  • Shortness of breath or wheezing

Other Side Effects

This medicine can also cause other side effects. If any of the other side effects listed in the manufacturer's pamphlet or those below happen to you please stop taking the medicine and call or message us or see your doctor in-person:

  • Abdominal pain
  • Dizziness
  • Dark red urine
  • Headache
  • Lightheadedness or passing out
  • Nausea
  • Vomiting
  • Metallic taste
  • Yeast Infection (Fungal Vaginitis)

Medicines, Supplements, and Foods

We have evaluated your health history and the specific health information you provided us, however, if anything changes and you start or discover that you are taking any of the medicines, foods, or supplements listed below call or message us before you take the medicine. Some of these can cause dangerous interactions with the medicine we are prescribing you and we will help you evaluate that risk and decide on an appropriate treatment plan:

  • HIV medications
  • Birth control (all hormonal)
  • Narcotic pain medications
  • Anti-seizure medications
  • Antipsychotic medications

Accurate Information

We have evaluated the specific health information you provided and are making our recommendations based on it. If you forgot to provide or incorrectly provided that information we may misdiagnose or fail to diagnose conditions that you may have which could affect our recommendation for treatment. If you need to clarify or update any information about your health you can message or call us anytime.

Treatment Failure

This treatment is not 100% effective. It may not work or may only partially resolve the condition for which you are seeking treatment. If the treatment is not working, or if you are experiencing new or worsening symptoms, give us a call or message us anytime. If it is an emergency call 911 or seek immediate medical help in-person. You may need to seek alternative treatment such as those listed below or in the follow-up plan.

Misdiagnosis or Delayed Diagnosis

There is also a risk that we may incorrectly diagnose or fail to diagnose the correct conditions that you may have, thereby affecting our recommendation for treatment. This risk exists with in-person care as well, but they may have additional clinical history, physical exam findings and tests to aid their evaluation. We use evidence-based practice guidelines and clinical decision making to try to minimize these risks. Here are some other diagnoses that we attempt to rule out:

  • Sexally transmitted Infections (STI)
  • Yeast Infections
  • Urinary Tract Infections (UTI)

Accepting or Declining Our Recommendation

We are recommending this treatment for you because the potential benefits of treatment outweigh the risks. You should evaluate this information as well as the manufacturer's pamphlet, and any input from your in-person healthcare team, or other relevant information to decide if this treatment plan is appropriate for you. You are free to decline our treatment recommendations although doing so may prolong symptoms and can be associated with other risks or negative outcomes.

Alternative Treatment

We have based our recommendation on your specific case and current medical guidelines, but there may be alternative treatments or strategies that may be helpful to you. Some may be more or less effective than what we provide. Some treatments may require an in-person exam or procedure which we can't provide. Message us or talk to your doctor in-person to discuss alternative treatments. Here are some other treatments or strategies that you might consider:

  • In-person Pelvic exam with testing

Share with Your In-Person Healthcare Team

You can access your records anytime. We strongly recommend that you update your in-person doctor, pharmacist, and the rest of your healthcare team to let them know about any new medicines you are taking or other changes in your health.

You can also ask us questions anytime and we are happy to help you share any information about your health with your in-person healthcare team.