Hand holding a single Fluconazole pill with a pink background

Everything You Need to Know About Fluconazole -
The One Pill Yeast Infection Cure

By Kathleen Morrison
October 5, 2021

Anyone who’s felt that familiar yeast infection itch knows that when it strikes, you’re looking for relief — fast. Over-the-counter creams are some of the first treatments people turn to, but they can be messy and often require multiple applications to work. Doctors tend to prefer a prescription yeast medication called fluconazole (Diflucan). These yeast pills are just that — a fluconazole 150 mg tablet that you take orally. It’s simple and easy to take and is one of the most effective and reliable yeast infection treatments. If you’re looking for an easy yeast infection solution and are considering fluconazole, here’s what you need to know.

How does fluconazole work?

Fluconazole is a prescription-strength antifungal. Yeast infections happen when something disrupts your vagina’s natural pH balance and natural balance of bacteria. This disruption can lead to an overgrowth of Candida, a yeast infection-causing fungus that often exists in your vagina without causing any problems. However, when populations of Candida increase it leads to inflammation, unusual discharge (people often describe it as having a “cottage cheese” look and texture), and that dreaded itch. Fluconazole helps your body fight back against Candida by limiting its ability to multiply and killing off existing yeast cells. Often, 1 fluconazole 150 mg tablet is enough to treat a yeast infection completely, but if not, a second tablet will get the job done.

Should I take fluconazole for a yeast infection?

If you are someone who experiences recurring yeast infections or are sure you have a yeast infection, fluconazole is a great option! It’s a very effective medication and can work to interrupt a cycle of frequent infections. Plus, it’s very affordable and easy to buy fluconazole online through Wisp. Yeast infections do have symptoms that overlap with other common vaginal infections, so if you aren’t quite sure what you’re dealing with you can always take Wisp’s Symptoms Quiz or message a doctor to ask questions. Typically, yeast infection symptoms consist of:

  • Itch
  • White and chunky discharge
  • Odorless discharge, or a very mild yeast infection smell
  • Burning when urine touches raw, irritated skin

A yeast infection can also be confused with Bacterial Vaginosis, but there are key differences when it comes to BV symptoms:

  • Intense “fishy” vaginal odor
  • Thin grey or greenish discharge
  • Itch
  • Burning during urination If you’re experiencing unusual odor and grey or green discharge, you’re likely dealing with BV. But if you just aren’t sure, it’s always best to consult with a doctor who can provide the proper diagnosis and treatment!

When should I take a second fluconazole?

Once you’re sure you have a yeast infection and decide to get prescription fluconazole treatment, your Wisp medical provider will likely prescribe two 150 mg tablets. If your symptoms don’t improve in 2 days, you should take the second dose of 150 mg fluconazole. The second dose simply adds a little more antifungal power to treat a stubborn infection. Should your symptoms fail to improve within a week, let your provider know and they may prescribe you a different medication, or a more intensive treatment regimen with fluconazole.

Get Yeast Infection Medication Online


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Fluconazole (Diflucan) 150mg

The most common prescription antifungal used to treat vaginal yeast infections.

Starting at $15.00

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Bottle of BV antibiotics to treat bacterial vaginosis on a pink background and red surface

Metronidazole (Flagyl) For BV

The most affordable topical prescription antibiotic for treating bacterial vaginosis.

Starting at $15.00

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Boric Acid Suppositories

An over-the-counter vaginal suppository custom-made to help prevent & relieve infections.

Starting at $27.00

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Wisp Equalizing Probiotics

Custom formulated by our doctors to support immune, gut, vaginal + oral health, cholesterol levels, and more.

Starting at $74.00

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Why does my Yeast Infection keep coming back?

Many people experience recurrent or chronic yeast infection symptoms that leave them wondering, “Why does my yeast infection keep coming back?” There are a few different possible causes of these repeat symptoms:

  • Your initial infection wasn't treated completely
  • You're creating humid or moist conditions for Candida to thrive
  • You have a drug-resistant strain of yeast
  • Your vaginal bacteria is out of whack
  • You have a weakened immune system

At the end of the day, your body chemistry might just make you a bit more prone to yeast infections. Staying clean and dry in cotton undies, sticking with loose-fitting clothes, and making sure you get treatment from a doctor when you have yeast infection symptoms are all great ways to stay on top of your vaginal health and break a cycle of recurrent infections. You can always use Wisp to get an online yeast infection prescription, if deemed safe and appropriate by Wisp's licensed medical providers, or browse yeast infection treatment online. Boric Acid and Wisp Equalizing Probiotics can be great additions to your yeast infection toolkit. Taking Boric Acid in addition to fluconazole you buy online can help speed recovery and prevent infections in the future. Integrating Wisp Equalizing Probiotics into your routine can also help your vaginal flora thrive and contribute to a healthy microbiome.

Can you get Yeast Infections from sex?

If you do have frequent yeast infections, especially if they occur after sex, you may be wondering if you can get a yeast infection from sex. Yes, it's entirely possible for sex to trigger a yeast infection, but that doesn't mean it's an STI. Sex can be a contributing factor in disrupting your vaginal ecosystem, which in turn can lead to a yeast infection. In rare cases, a person with a penis can get a yeast infection if they have vaginal sex with someone who has a yeast infection. It's also possible to pass yeast infections between female partners. That's why it's usually best to put yourself out of commission until your infection clears up.

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