We've all had the unpleasant experience of a hangover after a few too many drinks, or have gotten a little too adventurous trying new foods while on vacation. Zofran is a prescription anti-nausea treatment that works fast to soothe your stomach and get you back on track! Not only is it a travel essential for emergencies, but it can also help address nausea caused by medications like antibiotics, birth control, and emergency contraception (pro-tip: we offer Zofran as an add-on to purchase with certain treatments!). Learn more about this handy medication and how it could fit into your lifestyle!

What is Zofran?

Zofran belongs to a class of drugs called antiemetics, otherwise known as medications that prevent or stop vomiting. These types of drugs have all kinds of important uses and are used to provide relief from food poisoning, chemotherapy, post-surgery recovery, medication side effects, and more! While antiemetics don’t typically treat the root cause of nausea, they can help prevent the dehydration and loss of nutrients that comes from repeated vomiting, giving your other treatments time to work.

Zofran specifically is great to carry with you while traveling—it’s generally low-risk for most people and can be especially helpful for treating nausea from hangovers, indigestion, antibiotics, and hormone medications like birth control. Including it in your carry-on provides a little extra boost of confidence when you hop on the plane, especially when traveling to locations where you may be exposed to different bacteria than your body’s used to!

Note: Ginger or Dramamine are still the best treatments for nausea caused by motion sickness, so be sure to include them alongside Zofran for complete protection from planes, trains, automobiles, and boats!

How long does Zofran take to work?

Zofran is a serotonin blocker, also known as a serotonin 5-HT3 antagonist. Serotonin is a naturally occurring chemical signal in your body that plays a lot of different roles and is involved in things like your mood, sleep cycle, recovery, and, yes, digestion. In this case, Zofran is able to stop serotonin from telling your brain that you need to vomit, thus relieving those yucky waves of nausea at the source. It typically takes about 30 minutes for Zofran to kick in, so it’s best to take Zofran in advance if you can, to prevent nausea altogether.

Where can I get Zofran?

Previously, Wisp only had Zofran as an add-on with certain treatments and medications known to cause nausea, like antibiotics and emergency contraception. However, we’ve now made Zofran available as a standalone product so you can keep it in your medicine cabinet for when you need it most! While Zofran isn’t available over the counter, we make it easy to order Zofran online and have it delivered straight to your door. That means no annoying waits or appointments for this endlessly useful nausea medication!

How long does Zofran last?

The effects of Zofran last several hours, and it’s safe to take 1 tablet every 8 hours (do not exceed 3 tablets in 24 hours). It starts working after 30 mins and reaches its full effect after 2 hours. Side effects with Zofran are rare, but it is possible to experience mild side effects such as:

• Constipation
• Headache
• Drowsiness
• Diarrhea

Zofran can make you sleepy, so exercise caution and plan accordingly if you are trying this medication for the first time.

One important benefit is that Zofran can be taken with or without food! It can be hard to eat when you are feeling nauseous, so don’t feel pressure to eat before taking it. You will tolerate it just fine!

Who shouldn’t take Zofran?

While Zofran is generally well tolerated, and extremely helpful when experiencing nausea after starting a new medication, there are some drug interactions you’ll want to watch for.

Zofran is a serotonin receptor blocker—if serotonin receptors are blocked, there will be more serotonin circulating around your body. An increase in circulating serotonin can be dangerous because there are other medications that allow for increased serotonin in your body—medications that help with anxiety, depression (SSRI’s), migraine medications (Triptans), and antibiotics like Linezolid. If you are on one of the mentioned medications while taking Zofran, you may be putting yourself at risk for Serotonin Syndrome, a condition that occurs when your serotonin levels are dangerously high. This syndrome can have mild symptoms such as experiencing shakiness, trouble sleeping, excessive sweating. More extreme symptoms are high fever, uncontrollable diarrhea, and uncontrollable shaking and body movements. Of note, if any of those side effects are to occur while taking Zofran, please stop taking the medication and seek medical attention immediately.

Additionally, while Cardiac side effects are definitely rare with Zofran, there are some reports of QT elongation when taking this medication, which is quite dangerous causing the heart to take longer to contract and relax. Who is at risk for this? Those who are taking antiarrhythmic medication, people with low potassium or magnesium levels, those who take antibiotics from the Fluroquinolone family (Ciprofloxacin, levaquin), or Macrolide family (Azithromycin).

If you have a history of the below mentioned conditions, you should speak to your medical provider before taking Zofran:

• Heart disease
• History of irregular heartbeat
• Liver disease
• Low levels of magnesium or potassium in the blood
• An unusual or allergic reaction to ondansetron, granisetron, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Anxiety/depression and on SSRI’s
• History of PKU
• Breast-feeding

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