Wisp glass jar on pink and red surface with two pills outside the bottle

When To Take A Second
Fluconazole For Yeast Infection

By Kathleen Morrison
October 6, 2021

Yeast infections are frustrating, irritating, and uncomfortable.If you’ve had one before, you’ll always recognize the symptoms and you’ll want to find relief fast. There are lots of over-the-counter solutions you can find at the drugstore, but the most frequently prescribed yeast infection medication is fluconazole, a 1 pill yeast infection cure. Fluconazole (also known as Diflucan) is a strong antifungal, trusted by doctors, that tackles yeast infections from the inside out. Even though it’s highly effective, yeast infections can be very stubborn so Wisp providers will often prescribe 2 doses of this medication just in case the first one doesn’t quite knock out your symptoms. But how do you know when to take your second dose?

How long does fluconazole take to work?

First, you need to know when to expect to start seeing results from taking your first dose of fluconazole. This time frame can vary depending on the severity of your infection and how your body is handling it, but vaginal yeast infections typically take about 24 hours to begin responding to a dose of fluconazole. You should begin to see experience a reduction in itchiness, irritation, and chunky discharge. If you don't begin feeling better in about 3 days, you'll want to let your doctor know and get a second dose of fluconazole if you don't have one already.

When should I take second fluconazole 150 mg?

Once you’re sure you have a yeast infection and decide to get prescription fluconazole treatment, your Wisp provider will likely prescribe two 150 mg tablets. If your symptoms don’t improve in 2 days, you should take the second dose of 150 mg fluconazole. The second dose simply adds a little more antifungal power to treat a stubborn infection. If your symptoms do not see any improvement within a week, let your medical provider know and they may prescribe you a different medication, or a more intensive treatment regimen with fluconazole.

Why does my Yeast Infection keep coming back?

Many people experience recurrent or chronic yeast infection symptoms that leave them wondering, “Why does my yeast infection keep coming back?” There are a few different possible causes of these repeat symptoms:

  • Your initial infection wasn't treated completely
  • You're creating humid or moist conditions for Candida to thrive
  • You have a drug-resistant strain of yeast
  • Your vaginal bacteria is out of whack
  • You have a weakened immune system

How do I know if I still have a Yeast Infection?

Chronic yeast infection symptoms should be pretty familiar to you if you've experienced even one yeast infection. However, these symptoms often overlap with other common vaginal infections like BV. If you aren’t quite sure what you’re dealing with you can always take Wisp’s Symptoms Quiz or message a provider to ask questions. Typically, chronic yeast infection symptoms consist of:

  • Itch
  • White and chunky discharge
  • Odorless discharge, or a very mild yeast infection smell
  • Burning when urine touches raw, irritated skin

What's the difference between a Yeast Infection and BV?

A yeast infection can also be confused with Bacterial Vaginosis, but there are key differences when it comes to BV Symptoms, such as:

  • Intense “fishy” vaginal odor
  • Thin grey or greenish discharge
  • Itch
  • Burning during urination

If you’re experiencing unusual odor and grey or green discharge, you’re likely dealing with BV. But if you just aren’t sure, it’s always best to who can provide the proper diagnosis and treatment!

What happens after taking a second Fluconazole?

Be patient and allow the medication to take effect. Your body won't heal immediately, but you should notice improvement within a day or two. If you are prone to yeast infections it may mean your body chemistry takes a bit more time to regain its balance. Staying clean and dry in cotton undies, sticking with loose-fitting clothes, and making sure you get treatment from a doctor when you have yeast infection symptoms are all great ways to stay on top of your vaginal health and break a cycle of recurrent infections. Boric Acid and Wisp Equalizing Probiotics can be great additions to your yeast infection toolkit. Taking in addition to can help speed recovery and prevent infections in the future. Integrating into your routine can also help your vaginal flora thrive and contribute to a healthy microbiome.

If you’re looking for tips to prevent yeast infections, or a place to connect with others who are going through the same thing, check us out on Instagram @hellowisp! We share remedies, knowledge, and experiences from doctors, sexperts, and other Wispers who’ve been there. To read a third-party review of Wisp, check out Honest Brand Reviews for more info!

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Fluconazole (Diflucan) 150mg

The most common prescription antifungal used to treat vaginal yeast infections

Starting at $15.00

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BV Antibiotics (Tablets or Gel)

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Boric Acid Suppositories

An over-the-counter vaginal suppository custom made to help prevent & relieve infections.

Starting at $27.00

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Wisp Equalizing Probiotics

Custom formulated by our doctors to support immune, gut, vaginal + oral health, cholesterol levels, and more.

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