Studies show that women’s skin loses about 30% of its collagen during the first five years of menopause! The best way to turn back the clock? Restore the hormones lost to menopause. Topical estriol works locally where applied to help restore collagen, elasticity, and moisture for a brighter, glowier complexion. Consistency is key: your skin renews itself every 40-56 days, so it typically takes at least that long to see the effects of changes to your routine!