We've all had the unpleasant experience of a morning after a few too many drinks, or have gotten a little too adventurous trying new foods while on vacation. Zofran, or it's generic form Ondansetron, is a prescription anti-nausea treatment that works fast to soothe your stomach and get you back on track! If you're wondering how to take Ondansetron, don't worry—our oral dissolving tablets work quickly, taking as little as 30 minutes to start working. Take your Zofran dosage 30 minutes before triggering events or when you begin feeling ill and you'll experience its full effect after about 2 hours.